The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2014
Filed:
May. 26, 2006
Applicants:
LI Deng, Newton, MA (US);
Hongming LI, Waltham, MA (US);
Inventors:
Li Deng, Newton, MA (US);
Hongming Li, Waltham, MA (US);
Assignee:
Brandeis University, Waltham, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 453/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
One aspect of the present invention relates to asymmetric catalytic nitroaldol (Henry) reactions with ketones as the electrophilic component. In one embodiment, the present invention relates to asymmetric nitroaldol reactions with α-keto esters catalyzed by a new C6'-OH cinchona alkaloid catalyst. In certain embodiments, this reaction is operationally simple and affords high enantioselectivity as well as good to excellent yield for an exceptionally broad range of α-keto esters.