The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2014
Filed:
Oct. 22, 2009
Elena Feinstein, Rehovot, IL;
Evgenia Alpert, Jerusalem, IL;
Igor Mett, Rehovot, IL;
Amir Bar-ilan, Haifa, IL;
Igor Spivak, Haifa, IL;
Hagar Kalinski, Rishon-le-Zion, IL;
Netanja Slager, Tel Aviv, IL;
James D. Thompson, Longmont, CO (US);
Elena Feinstein, Rehovot, IL;
Evgenia Alpert, Jerusalem, IL;
Igor Mett, Rehovot, IL;
Amir Bar-Ilan, Haifa, IL;
Igor Spivak, Haifa, IL;
Hagar Kalinski, Rishon-le-Zion, IL;
Netanja Slager, Tel Aviv, IL;
James D. Thompson, Longmont, CO (US);
Quark Pharmaceuticals, Inc., Fremont, CA (US);
Abstract
The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.