The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2014
Filed:
Jun. 21, 2011
Applicants:
Kapil Mehta, Bellaire, TX (US);
Anupam Kumar, Houston, TX (US);
Jansina Fok, Houston, TX (US);
Shuxing Zhang, Pearland, TX (US);
Inventors:
Kapil Mehta, Bellaire, TX (US);
Anupam Kumar, Houston, TX (US);
Jansina Fok, Houston, TX (US);
Shuxing Zhang, Pearland, TX (US);
Assignee:
Board of Regents, The University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 333/34 (2006.01); C07D 259/00 (2006.01); C07D 333/24 (2006.01); C07D 333/04 (2006.01); A61K 31/381 (2006.01); A61K 31/41 (2006.01);
U.S. Cl.
CPC ...
C07D 333/04 (2013.01); C07D 275/023 (2013.01); A61K 31/381 (2013.01); A61K 31/41 (2013.01);
Abstract
Methods and compounds for treating cancer, dmg resistance and/or metastasis are described herein. These methods and compounds can inhibit the expression of aberrant TG2 expression and/or inhibit the binding of GTP to TG2, and thereby prevent the induction of epithelial to mesenchymal transition of cancer cells, and a stem cell-like phenotype.