The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 01, 2014

Filed:

Jan. 22, 2010
Applicants:

Andrew Paul Combs, Kennett Square, PA (US);

Richard B. Sparks, Boothwyn, PA (US);

Eddy Wai Tsun Yue, Landenberg, PA (US);

Hao Feng, Aston, PA (US);

Michael Jason Bower, Newark, DE (US);

Wenyu Zhu, Media, PA (US);

Inventors:

Andrew Paul Combs, Kennett Square, PA (US);

Richard B. Sparks, Boothwyn, PA (US);

Eddy Wai Tsun Yue, Landenberg, PA (US);

Hao Feng, Aston, PA (US);

Michael Jason Bower, Newark, DE (US);

Wenyu Zhu, Media, PA (US);

Assignee:

Incyte Corporation, Wilmington, DE (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/33 (2006.01); C07D 487/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.


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