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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8765376 B1

PDFFull Text
Expired
Date of Patent:
Jul. 01, 2014

Filed:

Sep. 10, 2009

Methods for identifying and compounds useful for increasing the functional activity and cell surface expression of cf-associated mutant cystic fibrosis transmembrane conductance regulator

Applicants:

David Frederik Fischer, Leiden, NL;

Richard Antonius Jozef Janssen, Leiden, NL;

Marjet Roseboom, Haarlem, NL;

Amelia Katie Scaffidi, Hillarys, AU;

Michela Tessari, Leiden, NL;

Inventors:

David Frederik Fischer, Leiden, NL;

Richard Antonius Jozef Janssen, Leiden, NL;

Marjet Roseboom, Haarlem, NL;

Amelia Katie Scaffidi, Hillarys, AU;

Michela Tessari, Leiden, NL;

Assignee:

Galapagos NV, Mechelen, BE;

Attorney:

Klauber & Jackson, LLC

Primary Examiner:

Sean McGarry

Int. Cl.
CPC ...
A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61P 1/16 (2006.01); C12N 15/11 (2006.01); G01N 33/68 (2006.01); C07H 21/02 (2006.01); C12Q 1/68 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
C12N 15/111 (2013.01); G01N 33/6872 (2013.01); C12N 2310/14 (2013.01); C12N 2330/31 (2013.01); G01N 2800/382 (2013.01);
Abstract

The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF-associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).

Find Patent Forward Citations

Fischer, David. (2014). Methods for identifying and compounds useful for increasing the functional activity and cell surface expression of cf-associated mutant cystic fibrosis transmembrane conductance regulator (U.S. Patent No. 8765376). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8765376

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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