The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2014
Filed:
Mar. 11, 2010
Zvia Agur, Tel Aviv, IL;
Oleg U. Kirnasovsky, Petach Tikva, IL;
Yuri Kogan, Jerusalem, IL;
Lilach Tencer, Rehovot, IL;
Zvia Agur, Tel Aviv, IL;
Oleg U. Kirnasovsky, Petach Tikva, IL;
Yuri Kogan, Jerusalem, IL;
Lilach Tencer, Rehovot, IL;
Institute for Medical Biomathematics, Bene Ataroth, IL;
Abstract
A method of determining a therapeutic regimen for the treatment of cancer with Dickkopf (Dkk) protein in which a mathematical model of differential equations describing the major signaling pathways involved in stem cell regulation is created and used to simulate signals from the cancer stem cell environment based upon administration of at least a single dose of Dkk in vitro and/or in vivo. A method of modulating cancer stem cells is also provided in which the stem cell computer model is simulates the effect of Dkk and performs a calibration test to determine a threshold value above which Dkk induces cell differentiation and a threshold value below which Dkk induces stem cell proliferation.