The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2014
Filed:
Sep. 01, 2010
Matthew Allen Zajac, King of Prussia, PA (US);
Matthew Allen Zajac, King of Prussia, PA (US);
Convergence Pharmaceuticals Limited, London, GB;
Abstract
The present application provides a process for the preparation of α-carboxamide pyrrolidine derivatives of formula (I), wherein Rand Rare independently hydrogen, Calkyl or CcycloalkylCalkyl; or such Rand R, together with the nitrogen to which they are attached, may form an unsubstituted 3-, 4-, 5- or 6-membered saturated ring; X is carbon or nitrogen; n is 0, 1 or 2, wherein when present each Ris independently selected from the list consisting of Calkyl, halogen, cyano, haloCalkyl, hydroxy, Calkoxy and Chaloalkoxy; either Ror Ris —O—R, —OCHRR, —NCHRor —(CH)Rwherein the other Ror Ris hydrogen or R; and wherein Ris a phenyl ring or wherein the phenyl ring is optionally substituted by one or more groups independently selected from the list consisting of Calkyl, halogen, cyano, haloCalkyl, hydroxy, Calkoxy and Chaloalkoxy; and Ris hydrogen or Calkyl.