The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2014
Filed:
Nov. 26, 2010
Kalet León Monzón, Ciudad de la Habana, CU;
Tania Carmenate Portilla, Ciudad de la Habana, CU;
Karina García Martínez, Ciudad de la Habana, CU;
Augustín Bienvendo Lage Davila, Habana, CU;
Samuel Pérez Rodríguez, Provincia Habana, CU;
Diamile González Roche, Ciudad de la Habana, CU;
Gabriel Márquez Perera, Ciudad de la Habana, CU;
Kalet León Monzón, Ciudad de la Habana, CU;
Tania Carmenate Portilla, Ciudad de la Habana, CU;
Karina García Martínez, Ciudad de la Habana, CU;
Augustín Bienvendo Lage Davila, Habana, CU;
Samuel Pérez Rodríguez, Provincia Habana, CU;
Diamile González Roche, Ciudad de la Habana, CU;
Gabriel Márquez Perera, Ciudad de la Habana, CU;
Centro de Inmunologia Molecular, La Habana, CU;
Abstract
The present invention relates generally to polypeptides whose primary sequence has high sequence homology with human interleukin 2 (IL-2) with some punctual mutations in the sequence of native IL-2. The polypeptides of the present invention have an immunomodulatory effect on the immune system, which is selective/preferential on regulatory T cells. The present invention also relates to specific polypeptides whose amino acid sequence is disclosed herein. In another aspect the present invention relates to pharmaceutical compositions comprising as active ingredient the polypeptides disclosed. Finally, the present invention relates to the therapeutic use of the polypeptides and pharmaceutical compositions disclosed due to their immune modulating effect on diseases such as cancer and chronic infectious diseases.