The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2014
Filed:
Apr. 25, 2008
David A. Stein, Corvallis, OR (US);
Richard K. Bestwick, Corvallis, OR (US);
Patrick L. Iversen, Corvallis, OR (US);
Benjamin Neuman, Encinitas, CA (US);
Michael Buchmeier, Encinitas, CA (US);
Dwight D. Weller, Corvallis, OR (US);
David A. Stein, Corvallis, OR (US);
Richard K. Bestwick, Corvallis, OR (US);
Patrick L. Iversen, Corvallis, OR (US);
Benjamin Neuman, Encinitas, CA (US);
Michael Buchmeier, Encinitas, CA (US);
Dwight D. Weller, Corvallis, OR (US);
Sarepta Therapeutics, Inc., Corvallis, OR (US);
The Scripps Research Institute, La Jolla, CA (US);
Abstract
A method and oligonucleotide compound for inhibiting replication of a nidovirus in virus-infected animal cells are disclosed. The compound (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the infected cells, (iii) contains between 8-25 nucleotide bases, and (iv) has a sequence capable of disrupting base pairing between the transcriptional regulatory sequences in the 5' leader region of the positive-strand viral genome and negative-strand 3′ subgenomic region. In practicing the method, infected cells are exposed to the compound in an amount effective to inhibit viral replication.