The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2014
Filed:
Jul. 22, 2010
Zheng Xin Dong, Holliston, MA (US);
Nicholas C. Prairie, Franklin, MA (US);
Maria L. Ufret, North Grafton, MA (US);
Jundong Zhang, Newton, MA (US);
Deborah M. Rothman, Arlington, MA (US);
Jeanne Mary Comstock, West Boylston, MA (US);
Zheng Xin Dong, Holliston, MA (US);
Nicholas C. Prairie, Franklin, MA (US);
Maria L. Ufret, North Grafton, MA (US);
Jundong Zhang, Newton, MA (US);
Deborah M. Rothman, Arlington, MA (US);
Jeanne Mary Comstock, West Boylston, MA (US);
Ipsen Pharma S.A.S., Paris, FR;
Abstract
The present invention relates to novel analogues of insulin-like growth factor-1 (IGF-1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1-receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treatment, and cartilage repair. More particularly, the present invention relates to novel analogues of IGF-1 having an amino acid substitution at position 59, e.g., (Asn)hIGF-1(1-70)-OH (SEQ ID NO:1), and other substitution(s) as defined herein.