The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2014
Filed:
Apr. 05, 2011
Andrew A. Young, Research Triangle Park, NC (US);
Will Vine, Poway, CA (US);
Kathryn Prickett, Foster City, CA (US);
Nigel R.a. Beeley, Solana Beach, CA (US);
Andrew A. Young, Research Triangle Park, NC (US);
Will Vine, Poway, CA (US);
Kathryn Prickett, Foster City, CA (US);
Nigel R.A. Beeley, Solana Beach, CA (US);
Amylin Pharmaceuticals, LLC, San Diego, CA (US);
AstraZeneca Pharmaceuticals LP, Wilmington, DE (US);
Abstract
Methods for increasing urine flow are disclosed, comprising administration of an effective amount of GLP-1, an exendin, or an exendin or GLP-1 agonist. Methods for increasing urinary sodium excretion and decreasing urinary potassium concentration are also disclosed. The methods are useful for treating conditions or disorders associated with toxic hypervolemia, such as renal failure, congestive heart failure, nephrotic syndrome, cirrhosis, pulmonary edema, and hypertension. The present invention also relates to methods for inducing an inotropic response comprising administration of an effective amount of GLP-1, an exendin, or an exendin or GLP-1 agonist. These methods are useful for treating conditions or disorders that can be alleviated by an increase in cardiac contractility such as congestive heart failure. Pharmaceutical compositions for use in the methods of the invention are also disclosed.