The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2014
Filed:
Dec. 13, 2010
Murugappan Muthukumar, Amherst, MA (US);
Zhaoyang Ou, Webster, NY (US);
Deniz Civay, Rensselaer, NY (US);
Murugappan Muthukumar, Amherst, MA (US);
Zhaoyang Ou, Webster, NY (US);
Deniz Civay, Rensselaer, NY (US);
University of Massachusetts, Boston, MA (US);
Abstract
Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a β-crystallin electrostatic interaction inhibitor. Both presbyopia and cataracts are caused by aggregation of the soluble crystalline lens proteins called the crystallins, particularly β-crystallin. It has been found that the aggregation of β-crystallin is an electrostatic phenomenon and that electrostatic interaction inhibitors can be employed to prevent the formation of β-crystallin aggregates as well as to deaggregate already formed aggregates.