The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2014
Filed:
Aug. 28, 2013
Immunomedics, Inc., Morris Plains, NJ (US);
Christopher A. D'Souza, Pomona, NY (US);
William J. McBride, Boonton, NJ (US);
David M. Goldenberg, Mendham, NJ (US);
Immunomedics, Inc., Morris Plains, NJ (US);
Abstract
The present application discloses compositions and methods of synthesis and use ofF orF-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, theF orF is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may be directly or indirectly attached to the targeting molecule. In other embodiments, theF orF labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the labeled molecule may be used for imaging in a subject without purification after labeling.