IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8754209 B1

PDFFull Text
Date of Patent:
Jun. 17, 2014

Filed:

Dec. 04, 2009

Indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient

Applicants:

Tae BO Sim, Daegu, KR;

Jung Beom Son, Seoul, KR;

Hwan Kim, Goyang-si, KR;

Dong Sik Park, Busan, KR;

Hwan Geun Choi, Seoul, KR;

Young Jin Ham, Seoul, KR;

Jung MI Hah, Seoul, KR;

Kyung Ho Yoo, Seoul, KR;

Chang Hyun OH, Seoul, KR;

SO Ha Lee, Seoul, KR;

Jae Du Ha, Daejeon, KR;

Sung Yun Cho, Daejeon, KR;

Byoung Mog Kwon, Daejeon, KR;

Dong Cho Han, Daejeon, KR;

Inventors:

Tae Bo Sim, Daegu, KR;

Jung Beom Son, Seoul, KR;

Hwan Kim, Goyang-si, KR;

Dong Sik Park, Busan, KR;

Hwan Geun Choi, Seoul, KR;

Young Jin Ham, Seoul, KR;

Jung Mi Hah, Seoul, KR;

Kyung Ho Yoo, Seoul, KR;

Chang Hyun Oh, Seoul, KR;

So Ha Lee, Seoul, KR;

Jae Du Ha, Daejeon, KR;

Sung Yun Cho, Daejeon, KR;

Byoung Mog Kwon, Daejeon, KR;

Dong Cho Han, Daejeon, KR;

Assignees:

Korea Institute of Science and Technology, Daejeon, KR;

Korea Research Institute of Chemical Technology, Daejeon, KR;

Korea Research Institute of Bioscience and Biotechnology, Daejeon, KR;

Attorney:

Staas & Halsey LLP

Primary Examiner:

Rebecca Anderson

Int. Cl.
CPC ...
C07D 413/14 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 403/12 (2006.01); C07D 409/12 (2006.01); C07D 231/56 (2006.01);
U.S. Cl.
CPC ...
C07D 413/14 (2013.01); C07D 413/12 (2013.01); C07D 401/12 (2013.01); C07D 417/12 (2013.01); C07D 405/12 (2013.01); C07D 403/12 (2013.01); C07D 409/12 (2013.01); C07D 231/56 (2013.01);
Abstract

Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.

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