The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 2014
Filed:
Apr. 11, 2007
Samuel J. Danishefsky, Englewood, NJ (US);
J. David Warren, New York, NY (US);
Jiehao Chen, Westfield, IN (US);
Bin Wu, Thousand Oaks, CA (US);
Gong Chen, New York, NY (US);
Qian Wan, Quincy, MA (US);
Zhongping Tan, New York, NY (US);
Cindy Kan, New York, NY (US);
Yu Yuan, New York, NY (US);
Zihao Hua, Tewksbury, MA (US);
Krishnakumar Ranganathan, Oak Park, CA (US);
John D. Trzupek, Boston, MA (US);
Samuel J. Danishefsky, Englewood, NJ (US);
J. David Warren, New York, NY (US);
Jiehao Chen, Westfield, IN (US);
Bin Wu, Thousand Oaks, CA (US);
Gong Chen, New York, NY (US);
Qian Wan, Quincy, MA (US);
Zhongping Tan, New York, NY (US);
Cindy Kan, New York, NY (US);
Yu Yuan, New York, NY (US);
Zihao Hua, Tewksbury, MA (US);
Krishnakumar Ranganathan, Oak Park, CA (US);
John D. Trzupek, Boston, MA (US);
Sloan-Kettering Institute for Cancer Research, New York, NY (US);
Abstract
The present invention provides isolated homogeneous polyfunctionalized proteins (e.g., erythropoietin), isolated glycopeptides, and a method for preparing polyfunctionalized peptides and/or proteins via cysteine-free native chemical ligation. In certain embodiments, the invention provides an isolated homogeneous polyfunctionalized protein having the structure (I). In certain other embodiments, the invention provides an isolated glycopeptide having Formula (II). In certain other embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently substituted with a moiety having the structure (III) -LH. wherein A and L1 are as defined herein.