The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 17, 2014

Filed:

Jan. 11, 2011
Applicants:

Liangqin Guo, Edison, NJ (US);

William K. Hagmann, Westfield, NJ (US);

Shuwen He, Edison, NJ (US);

Zhong Lai, Scotch Plains, NJ (US);

Jian Liu, Edison, NJ (US);

Ravi P. Nargund, East Brunswick, NJ (US);

Shrenik K. Shah, Metuchen, NJ (US);

Quang T. Truong, Morganville, NJ (US);

Inventors:

Liangqin Guo, Edison, NJ (US);

William K. Hagmann, Westfield, NJ (US);

Shuwen He, Edison, NJ (US);

Zhong Lai, Scotch Plains, NJ (US);

Jian Liu, Edison, NJ (US);

Ravi P. Nargund, East Brunswick, NJ (US);

Shrenik K. Shah, Metuchen, NJ (US);

Quang T. Truong, Morganville, NJ (US);

Assignee:

Merck Sharp & Dohme Corp, Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01);
U.S. Cl.
CPC ...
Abstract

Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.


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