The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 2014
Filed:
Nov. 10, 2009
Mara Fornaro, Basel, CH;
John Xu, Shanghai, CN;
Yuan Gao, Shanghai, CN;
Rainer Hillenbrand, Basel, CH;
Francois Legay, Basel, CH;
Daniela Stoellner, Basel, CH;
Mara Fornaro, Basel, CH;
John Xu, Shanghai, CN;
Yuan Gao, Shanghai, CN;
Rainer Hillenbrand, Basel, CH;
Francois Legay, Basel, CH;
Daniela Stoellner, Basel, CH;
Novartis AG, Basel, CH;
Abstract
High-specificity antibodies can distinguish between modified (e.g, hIGF-1/Ea 3mut) and endogenous wild-type human IGF-1 proteins. These antibodies have little or no cross-reactivity with hIGF-1 or hIGF-2. They also have little or no cross-reactivity with rodent IGF-1 or IGF-2. The antibodies can be used in pharmacokinetic (PK)/pharamcodynamic (PD) assessments of IGF-1/E peptides that have been administered to humans or animals. A sandwich ELISA assay, using the antibody of the invention as a capture antibody, can quantify the mutant IGF-1/E proteins in samples.