The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2014
Filed:
Jan. 31, 2012
Marc Besman, Seattle, WA (US);
Stewart Chipman, Bainbridge Island, WA (US);
David Leung, Mercer Island, WA (US);
Jack Singer, Seattle, WA (US);
Marc Besman, Seattle, WA (US);
Stewart Chipman, Bainbridge Island, WA (US);
David Leung, Mercer Island, WA (US);
Jack Singer, Seattle, WA (US);
Cell Therapeutics, Inc., Seattle, WA (US);
Abstract
Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.