The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 10, 2014

Filed:

Dec. 14, 2010
Applicants:

Anja Kunert, Halle/Saale, DE;

Jörg Narkamp, Halle/Saale, DE;

Arnd Steuernagel, Göttingen, DE;

Markus Fiedler, Halle/Saale, DE;

Erik Fiedler, Halle/Saale, DE;

Thomas Göttler, Halle/Saale, DE;

Inventors:

Anja Kunert, Halle/Saale, DE;

Jörg Narkamp, Halle/Saale, DE;

Arnd Steuernagel, Göttingen, DE;

Markus Fiedler, Halle/Saale, DE;

Erik Fiedler, Halle/Saale, DE;

Thomas Göttler, Halle/Saale, DE;

Assignee:

Scil Proteins GmbH, Halle, DE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C40B 30/04 (2006.01); G01N 33/68 (2006.01); C07K 14/435 (2006.01); C07K 14/47 (2006.01); C12N 15/10 (2006.01); C40B 40/10 (2006.01); C40B 50/06 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1034 (2013.01); C12N 15/1037 (2013.01); C12N 15/1041 (2013.01); C07K 14/435 (2013.01); C07K 14/47 (2013.01); G01N 33/6845 (2013.01); G01N 33/6878 (2013.01);
Abstract

The present invention refers to a method for identifying hetero-multimeric ubiquitins with binding capability to a ligand. Furthermore, the invention provides DNA libraries encoding for a population of said hetero-multimeric ubiquitins as well as protein libraries obtained by expression of said DNA libraries, cells and phages containing said DNA or proteins, polynucleotides encoding for said fusion proteins and vectors comprising said polynucleotides. Further new binding proteins based on hetero-multimeric ubiquitin being able to bind specifically with high affinity to selected ligands are provided.


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