The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2014
Filed:
Jan. 28, 2011
Andreas Mershin, Cambridge, MA (US);
Brian Cook, San Francisco, CA (US);
Liselotte Kaiser, Tyreso, SE;
Johanna F. Bikker, SE Lexmond, NL;
Yoshikatsu Miura, Kyoto, JP;
Daisuke Niwa, Osaka, JP;
Dai Ohnishi, Ohtsu, JP;
Atsushi Tazuke, Kakogawa, JP;
Shuguang Zhang, Lexington, MA (US);
Andreas Mershin, Cambridge, MA (US);
Brian Cook, San Francisco, CA (US);
Liselotte Kaiser, Tyreso, SE;
Johanna F. Bikker, SE Lexmond, NL;
Yoshikatsu Miura, Kyoto, JP;
Daisuke Niwa, Osaka, JP;
Dai Ohnishi, Ohtsu, JP;
Atsushi Tazuke, Kakogawa, JP;
Shuguang Zhang, Lexington, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.