The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2014
Filed:
May. 11, 2012
Brad J. Spellberg, Rancho Palos Verdes, CA (US);
Lin Lin, Rancho Palos Verdes, CA (US);
Ashraf Ibrahim, Irvine, CA (US);
Guanpingsheng Luo, Torrance, CA (US);
Brad J. Spellberg, Rancho Palos Verdes, CA (US);
Lin Lin, Rancho Palos Verdes, CA (US);
Ashraf Ibrahim, Irvine, CA (US);
Guanpingsheng Luo, Torrance, CA (US);
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (US);
Abstract
The present invention provides vaccine compositions comprising OmpA, or antigenic fragments thereof, and related methods of active immunization againstinfection. The invention also provides antibodies and antigen-binding parts thereof that specifically bind to OmpA, and related methods of passive immunization againstinfection. The compositions and methods of the invention are useful for preventing or treatinginfections, including those caused by strains resistant to carbapenems and all other antibiotics except colistin or tigecycline, also referred to as extreme drug resistant (XDR)infections, and those resistant to every FDA approved antibiotic, also referred to as pan-drug resistant (PDR)infections.