The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 03, 2014

Filed:

Aug. 12, 2011
Applicants:

Joseph L. Duffy, Cranford, NJ (US);

Jianming Bao, Princeton, NJ (US);

Debra L. Ondeyka, Fanwood, NJ (US);

Sriram Tyagarajan, Edison, NJ (US);

Patrick Shao, Fanwood, NJ (US);

Feng YE, Scotch Plains, NJ (US);

Revathi Katipally, Monmouth Junction, NJ (US);

Aaron Zwicker, New Haven, CT (US);

Edward C. Sherer, Manville, NJ (US);

Michael A. Plotkin, Frenchtown, NJ (US);

Remond Moningka, Rahway, NJ (US);

Zahid Hussain, Dayton, NJ (US);

Harold B. Wood, Westfield, NJ (US);

Feroze Ujjainwalla, Scotch Plains, NJ (US);

F. Anthony Romero, Redwood City, CA (US);

Paul E. Finke, Milltown, NJ (US);

Yi Zang, Princeton, NJ (US);

Weiguo Liu, Princeton, NJ (US);

Inventors:

Joseph L. Duffy, Cranford, NJ (US);

Jianming Bao, Princeton, NJ (US);

Debra L. Ondeyka, Fanwood, NJ (US);

Sriram Tyagarajan, Edison, NJ (US);

Patrick Shao, Fanwood, NJ (US);

Feng Ye, Scotch Plains, NJ (US);

Revathi Katipally, Monmouth Junction, NJ (US);

Aaron Zwicker, New Haven, CT (US);

Edward C. Sherer, Manville, NJ (US);

Michael A. Plotkin, Frenchtown, NJ (US);

Remond Moningka, Rahway, NJ (US);

Zahid Hussain, Dayton, NJ (US);

Harold B. Wood, Westfield, NJ (US);

Feroze Ujjainwalla, Scotch Plains, NJ (US);

F. Anthony Romero, Redwood City, CA (US);

Paul E. Finke, Milltown, NJ (US);

Yi Zang, Princeton, NJ (US);

Weiguo Liu, Princeton, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 215/00 (2006.01); C07D 229/00 (2006.01); A61K 31/44 (2006.01); A61K 31/397 (2006.01);
U.S. Cl.
CPC ...
Abstract

Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.


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