The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2014
Filed:
Nov. 02, 2011
Applicants:
Maria-clemencia Hernandez, Delemont, CH;
Matthew C. Lucas, Verona, NJ (US);
Andrew Thomas, Binningen, CH;
Inventors:
Maria-Clemencia Hernandez, Delemont, CH;
Matthew C. Lucas, Verona, NJ (US);
Andrew Thomas, Binningen, CH;
Assignee:
Hoffmann-La Roche Inc., Nutley, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 403/10 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 491/107 (2013.01);
Abstract
The present invention is concerned with novel triazole compounds of formula (I) wherein A, X, Y, Z, R, R, and Rare as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of present invention have affinity and selectivity for the GABA A α5 receptor. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.