The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2014
Filed:
Feb. 05, 2013
The United States of America As Represented BY the Secretary of the Department of Health and Human Services, Rockville, MD (US);
Dennis M. Klinman, Potomac, MD (US);
Ken J. Ishii, Osaka, JP;
Daniela Verthelyi, Potomac, MD (US);
James J. Mond, Silver Spring, MD (US);
Abstract
A substantially pure or isolated oligodeoxynucleotide of at least 10 nucleotides is disclosed, wherein the oligodeoxynucleotide comprised a sequence represented by either formula:5' NNNT-CpG-WNNN3′wherein the CpG motif is unmethylated, W is A or T, and N, N, N, N, N, and Nare nucleotides, or the formula:5′ RY-CpG-RY 3′wherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host. In some embodiments, the oligodeoxynucleotide includes the nucleic acid sequences set forth as SEQ ID NO: 137.