The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 03, 2014

Filed:

Oct. 21, 2009
Applicants:

Bent Karsten Jakobsen, Oxfordshire, GB;

Torben Bent Andersen, Oxfordshire, GB;

Peter Eamon Molloy, Oxfordshire, GB;

Yi LI, Oxfordshire, GB;

Jonathan Michael Boulter, Blackwood, GB;

Inventors:

Bent Karsten Jakobsen, Oxfordshire, GB;

Torben Bent Andersen, Oxfordshire, GB;

Peter Eamon Molloy, Oxfordshire, GB;

Yi Li, Oxfordshire, GB;

Jonathan Michael Boulter, Blackwood, GB;

Assignees:

Immunocore Limited, Oxford, GB;

Adaptimmune Limited, Oxford, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C40B 40/10 (2006.01); C40B 30/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.


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