The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2014
Filed:
Jan. 20, 2005
Akihiro Iida, Ibaraki, JP;
Hiroshi Ban, Ibaraki, JP;
Makoto Inoue, Ibaraki, JP;
Takahiro Hirata, Ibaraki, JP;
Mamoru Hasegawa, Ibaraki, JP;
Akihiro Iida, Ibaraki, JP;
Hiroshi Ban, Ibaraki, JP;
Makoto Inoue, Ibaraki, JP;
Takahiro Hirata, Ibaraki, JP;
Mamoru Hasegawa, Ibaraki, JP;
DNAVEC Research Inc., Tsukuba-shi, Ibaraki, JP;
Abstract
The present invention provides methods for producing a minus-strand RNA viral vector, which comprise using a promoter comprising a cytomegalovirus enhancer and a chicken β-actin promoter, to induce the transcription of the genome RNA of a minus-strand RNA viral vector and the expression of minus-strand RNA viral proteins that form a ribonucleoprotein with the genome RNA. The methods of the present invention enable high efficiency production of highly safe minus-strand RNA viral vectors. The methods of the present invention are particularly useful for producing minus-strand RNA viral vectors that are deficient in envelope-constituting protein genes.