The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2014
Filed:
Dec. 06, 2010
Joaquin Arribas Lopez, Cerdanyola del Valles, ES;
Kim Pedersen, Barcelona, ES;
Pier-davide Angellini, Barcelona, ES;
Josep Lluis Parra Palau, Barcelona, ES;
Jose Baselga Torres, Barcelona, ES;
Joaquin Arribas Lopez, Cerdanyola del Valles, ES;
Kim Pedersen, Barcelona, ES;
Pier-Davide Angellini, Barcelona, ES;
Josep Lluis Parra Palau, Barcelona, ES;
Jose Baselga Torres, Barcelona, ES;
Abstract
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognise an epitope of the HER2 receptor truncated form CTF-611, said epitope being defined by a sequence included in SEQ ID NO: 2, and that are capable of discriminating between CTF-611 and CTF-616 (represented by SEQ ID NO:7), preferably additionally capable of discriminating between CTF-611 and CTF-613 (represented by SEQ ID NO:6). The invention also provides a method of cancer diagnosis using the disclosed antibodies, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample.