The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2014
Filed:
Aug. 27, 2010
Bing Chen, Chestnut Hill, MA (US);
Gary H. Frey, Nashua, NH (US);
Stephen C. Harrison, Brighton, MA (US);
Bing Chen, Chestnut Hill, MA (US);
Gary H. Frey, Nashua, NH (US);
Stephen C. Harrison, Brighton, MA (US);
Children's Medical Center Corporation, Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Howard Hughes Medical Institute, Chevy Chase, MD (US);
Abstract
Isolated, antigenic polypeptides including a prehairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Antibodies that bind to a prehairpin intermediate conformation of gp41 and methods of making antibodies a that bind to prehairpin intermediate conformation of gp41 are also provided. Vaccines against a prehairpin intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, prehairpin intermediate conformation of gp41 are further provided.