The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2014
Filed:
Aug. 17, 2011
Vadim Kraynov, San Diego, CA (US);
Nick Knudsen, San Diego, CA (US);
Ahma Hewet, Chula Vista, CA (US);
Kristine DE Dios, San Diego, CA (US);
Jason Pinkstaff, Encinitas, CA (US);
Lorraine Sullivan, San Diego, CA (US);
Vadim Kraynov, San Diego, CA (US);
Nick Knudsen, San Diego, CA (US);
Ahma Hewet, Chula Vista, CA (US);
Kristine De Dios, San Diego, CA (US);
Jason Pinkstaff, Encinitas, CA (US);
Lorraine Sullivan, San Diego, CA (US);
Ambrx, Inc., La Jolla, CA (US);
Abstract
Modified relaxin polypeptides and their uses are provided. In one aspect, the disclosure provides a relaxin polypeptide comprising one or more non-naturally encoded amino acids. The polypeptide may be linked to a linker, polymer, or biologically active molecule. The serum half-life of the relaxin polypeptide may be enhanced relative to the unconjugated form. In another aspect, the disclosure provides methods of treating a patient having a disorder modulated by relaxin.