The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2014
Filed:
Apr. 11, 2008
Yu-chie Chen, Hsinchu, TW;
Cheng-tai Chen, Taoyuan County, TW;
Wei-yu Chen, Taipei, TW;
Chun-yuen Lo, Kaohsiung, TW;
Hong-yi Lin, Taoyuan County, TW;
Chih-chi Liu, Chiayi, TW;
Yu-Chie Chen, Hsinchu, TW;
Cheng-Tai Chen, Taoyuan County, TW;
Wei-Yu Chen, Taipei, TW;
Chun-Yuen Lo, Kaohsiung, TW;
Hong-Yi Lin, Taoyuan County, TW;
Chih-Chi Liu, Chiayi, TW;
National Chiao Tung University, Hsinchu, TW;
Abstract
The present invention relates to a metal oxide nano-composite magnetic material, fabrication method, and method for linkage, enrichment, and isolation of phosphorylated species. The metal oxide nano-composite magnetic material comprises the magnetic iron oxide nanoparticle, a silica layer immobilized onto the magnetic iron oxide nanoparticle and a metal oxide layer coated onto the silica layer. The magnetic iron oxide nanoparticles can be used for absorbing microwave radiation to accelerate the enrichment and linkage for phosphorylated species onto the metal oxide nano-composite magnetic material. Furthermore, the magnetic property of magnetic iron oxide nanoparticles leads to isolation of the metal oxide nano-composite magnetic material-target species conjugates by simply employing an external magnetic field. The specificity of the metal oxide on the surface of the metal oxide nano-composite magnetic material for phosphorylated species also leads to the linkage/enrichment of phosphorylated species with high selectivity.