The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8735143 B1

PDF
Full Text
Expired
Date of Patent:
May. 27, 2014

Filed:

Mar. 21, 2011
Applicants:

Lanjuan LI, Hangzhou, CN;

Chengbo Yu, Hangzhou, CN;

Yiming Zhang, Hangzhou, CN;

Xiaoping Pan, Hangzhou, CN;

Weibo Du, Hangzhou, CN;

Hongcui Cao, Hangzhou, CN;

Guoliang LV, Hangzhou, CN;

Jianrong Huang, Hangzhou, CN;

Inventors:

Lanjuan Li, Hangzhou, CN;

Chengbo Yu, Hangzhou, CN;

Yiming Zhang, Hangzhou, CN;

Xiaoping Pan, Hangzhou, CN;

Weibo Du, Hangzhou, CN;

Hongcui Cao, Hangzhou, CN;

Guoliang Lv, Hangzhou, CN;

Jianrong Huang, Hangzhou, CN;

Assignee:

Zhejiang University, Hangzhou, Zhejiang, CN;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12M 3/00 (2006.01); C12N 5/00 (2006.01); A61M 1/14 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0062 (2013.01); C12M 3/00 (2013.01); A61M 1/14 (2013.01);
Abstract

The present invention provides a hepatic lobule-like bioreactor. The bioreactor includes a nanofiber scaffold enclosed within a housing. An intrahepatic fibrous vascular network, a bile capillary network, upper hepatic bile ducts, lower hepatic bile ducts, a common bile duct connecting the upper and the lower hepatic bile ducts, and collagen fibrous microchannels for hepatocytes surrounded by the bile capillary network are distributed throughout the nanofiber scaffold. Bile capillaries in the bile capillary network are provided with two or more inlet ports for biliary epithelial cells. The collagen fibrous microchannels for hepatocytes are provided with two or more inlet ports for hepatocytes. The intrahepatic vascular network is provided with a liquid inlet port and a liquid outlet port. These ports extend through the housing.


Find Patent Forward Citations

Li, Lanjuan. (2014). Hepatic lobule-like bioreactor (U.S. Patent No. 8735143). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8735143

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