The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2014
Filed:
May. 17, 2011
Chia-hung Lee, Tainan, TW;
Wei-neng Liao, New Taipei, TW;
Shih-hsun Cheng, Kaohsiung, TW;
Jen-kun Chen, Hsinchu, TW;
Chung-shi Yang, Taichung, TW;
Leu-wei Lo, New Taipei, TW;
Yeu-kuang Hwu, Taipei, TW;
Fong-sian Lin, Taichung, TW;
Chia-Hung Lee, Tainan, TW;
Wei-Neng Liao, New Taipei, TW;
Shih-Hsun Cheng, Kaohsiung, TW;
Jen-Kun Chen, Hsinchu, TW;
Chung-Shi Yang, Taichung, TW;
Leu-Wei Lo, New Taipei, TW;
Yeu-Kuang Hwu, Taipei, TW;
Fong-Sian Lin, Taichung, TW;
National Health Research Institutes, Miaoli County, TW;
Abstract
A method of synthesizing ligand-conjugated gold nanoparticles (AuNPs) is disclosed. The method comprises: a) providing an amine-modified silica particle; b) providing a solution comprising Auions; c) suspending the amine-modified silica particle in the solution comprising Auions; d) allowing the Auions to be adsorbed and/or immobilized onto the surface of the amine-modified silica particle; e) exposing the Auions immobilized onto the surface of the amine-modified silica particle to radiation to obtain bare gold nanoparticles (AuNPs) adsorbed and/or immobilized onto the surface of the amine-modified silica particle, wherein the bare AuNPs are without organic surface modifications; and f) reacting a ligand with the bare AuNPs adsorbed and/or immobilized onto the surface of the amine-modified SiNP and thereby obtain ligand-conjugated gold nanoparticles (AuNPs).