The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2014
Filed:
Apr. 30, 2007
Barbara Pui Chan, Ap Lei Chau, HK;
Kenneth Man-chee Cheung, Mid-Levels, HK;
Danny Chan, Ap Lei Chau, HK;
Godfrey Chi-fung Chan, Causeway Bay, HK;
Ting Yan Hui, Ma on Shan, HK;
Barbara Pui Chan, Ap Lei Chau, HK;
Kenneth Man-Chee Cheung, Mid-Levels, HK;
Danny Chan, Ap Lei Chau, HK;
Godfrey Chi-Fung Chan, Causeway Bay, HK;
Ting Yan Hui, Ma on Shan, HK;
University of Hong Kong, Hong Kong, HK;
Abstract
A bioengineered IVD for disc replacement has been developed that has mechanical and structural support characteristics similar to those of native IVD. Extracellular matrix (ECM) provides support to living cell components and interacts with the living cellular components during the fabrication process without introducing toxicity. The composition can be produced from both natural or synthetic source but preferably natural and induced to self-assemble or reconstitute into its solid form under conditions that are mild enough to support cellular survival and growth. The cells induce a volume change of the structures, leading to changes in dimension, ECM density, cell density, mechanical property and stability, etc. The extent of the change in volume of the composition can be precisely controlled by factors such as the density of the ECM, the density of the living cells, the timing for interaction and the serum concentration. Increased structural support is provided by crosslinking.