The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2014
Filed:
Oct. 18, 2012
National Research Council of Canada, Ottawa, CA;
Maureen D. O'Connor-McCourt, Beaconsfield, CA;
Traian Sulea, Kirkland, CA;
John C. Zwaagstra, Chomedey-Laval, CA;
Jason Baardsnes, Montreal, CA;
National Research Coucil of Canada, Ottawa, Ontario, CA;
Abstract
The invention provides multivalent ligand binding agents (traps) for members of the TGF-β superfamily and polypeptide linkers and methods for making and using such constructs. The traps may be used as therapeutic or diagnostic (imaging or non-imaging) agents for diseases/disorders caused by over-production/activity of the target ligand. In an embodiment of the invention there is provided a multivalent binding agent with affinity for a member of the TGF-β superfamily, the agent having the general structure I:(<bd1>-linker1)-[{<bd1>-linker2-<bd2>-linker3-}-(<bd3>)-(linker4-<bd4>)],where: