The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2014
Filed:
May. 31, 2011
Maribel Guerra Vallespi, Havana, CU;
Julio Raúl Fernández Massó, Havana, CU;
Alexis Musacchio Lasa, Artemisa, CU;
Jeovanis Gil Valdés, Havana, CU;
Osvaldo Reyes Acosta, Havana, CU;
Brizaida Maylin Oliva Argüelles, Havana, CU;
Maribel Guerra Vallespi, Havana, CU;
Julio Raúl Fernández Massó, Havana, CU;
Alexis Musacchio Lasa, Artemisa, CU;
Jeovanis Gil Valdés, Havana, CU;
Osvaldo Reyes Acosta, Havana, CU;
Brizaida Maylin Oliva Argüelles, Havana, CU;
Centro de Ingenieria Genetica y Biotecnologia, Havana, CU;
Abstract
This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.