The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2014
Filed:
Sep. 10, 2012
Jonathan B. Rothbard, Cupertino, CA (US);
Paul A. Wender, Menlo Park, CA (US);
Leo P. Mcgrane, Mountain View, CA (US);
Lalitha V. S. Sista, Sunnyvale, CA (US);
Thorsten A. Kirschberg, Mountain View, CA (US);
Jonathan B. Rothbard, Cupertino, CA (US);
Paul A. Wender, Menlo Park, CA (US);
Leo P. McGrane, Mountain View, CA (US);
Lalitha V. S. Sista, Sunnyvale, CA (US);
Thorsten A. Kirschberg, Mountain View, CA (US);
KAI Pharmaceuticals, Inc., South San Francisco, CA (US);
Abstract
This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length.