The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2014
Filed:
Jul. 06, 2010
Natasha Paul, San Diego, CA (US);
Jonathan Shum, Richmond, TX (US);
Alexandre Lebedev, San Diego, CA (US);
Gerald Zon, San Carlos, CA (US);
Natasha Paul, San Diego, CA (US);
Jonathan Shum, Richmond, TX (US);
Alexandre Lebedev, San Diego, CA (US);
Gerald Zon, San Carlos, CA (US);
Trilink Biotechnologies, San Diego, CA (US);
Abstract
Provided herein are methods for ligation of polynucleotides containing modified ligation components, particularly modified ligase cofactors, modified acceptors and modified donors. The methods readily applied to ligation-based assays for detection of a nucleic acid sequence where the use of the modified cofactor improves discrimination between matched and mismatched templates. Furthermore, the use of the modified ligation components reduces or eliminates the ligation in the absence of nucleic acid template.