The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2014
Filed:
Oct. 28, 2009
Shin-ichiro Nishimura, Sapporo, JP;
Hiroshi Hinou, Sapporo, JP;
Yoshito Numata, Osaka, JP;
Junji Onoda, Osaka, JP;
Shoichi Naito, Osaka, JP;
Naoki Ohyabu, Sapporo, JP;
Shin-Ichiro Nishimura, Sapporo, JP;
Hiroshi Hinou, Sapporo, JP;
Yoshito Numata, Osaka, JP;
Junji Onoda, Osaka, JP;
Shoichi Naito, Osaka, JP;
Naoki Ohyabu, Sapporo, JP;
National University Corporation Hokkaido University, Sapporo-Shi, Hokkaido, JP;
Shionogi & Co., Ltd., Osaka-Shi, Osaka, JP;
Abstract
An object of the present invention is to provide an antibody which does not bind to a normal cell, and is specific for a cancer cell. The object was solved by the finding by the present inventors that an antibody obtained by immunizing an animal using a 2,3ST glycopeptide as an antigen unexpectedly recognizes a sugar chain specific for a cancer specifically and remarkably, and consequently, can recognize and kill a cancer cell expressing MUC1 having such a cancer cell-specific sugar chain. The present invention provides, for example, an antibody, an antigen-binding fragment thereof or a MUC1-binding molecule, in which specificity for a cancer-associated structure of MUC1 is 100-fold or more as compared with that for a normal tissue-associated structure of MUC1.