Di-substituted pyridine derivatives as anticancers

Abstract

The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein Rand Rare aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G-, —N(lower alkyl)-G-, —NH—CH-G-, —N(lower alkyl)-CH-G- or —CH-G-, [wherein Gbinds to R, G-Ris bond-R, phenylene-G-R, phenylene-G-O—R, phenylene-G-NH—R, phenylene-G-N(lower alkyl)-Ror quinolinediyl-O—R, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G-Ris —O-lower alkylene-Ror the like; G-O— is lower alkylene-O— or the like; Gis lower alkylene; Gis lower alkylene].