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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8722638 B1

PDFFull Text
Date of Patent:
May. 13, 2014

Filed:

Jun. 19, 2009

Methods for the modulation of angiogenesis

Applicants:

Donald E. Ingber, Boston, MA (US);

Akiko Mammoto, Brookline, MA (US);

Inventors:

Donald E. Ingber, Boston, MA (US);

Akiko Mammoto, Brookline, MA (US);

Assignee:

Children's Medical Center Corporation, Boston, MA (US);

Attorneys:

David S. Resnick

Susanna C. Benn

Nixon Peabody LLP

Primary Examiner:

Dana Shin

Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 48/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to methods and compositions for promoting or inhibiting capillary endothelial (CE) cell migration, promoting or inhibiting the formation of CE networks and promoting or inhibiting angiogenesis. Some embodiments relate to methods and compositions for treating angiogenesis-related disorders characterized by loss or decreased angiogenesis. One aspect relates to the use of at least one pro-angiogenic agent selected from at least one of an p190RhoGAP inhibitor, a TFII-I inhibitor or a GATA-2 activator for promoting the formation of CE networks and angiogenesis, and methods for treating angiogenesis-related disorders characterized by loss or decreased angiogenesis. Another aspect of the invention related to use of at least one anti-angiogenic agent selected from at least one of an p190RhoGAP activator, a TFII-I activator or a GATA-2 inhibitor for inhibiting the formation of CE networks and inhibiting angiogenesis, and methods for treating angiogenesis-related disorders characterized by uncontrolled or elevated angiogenesis.

Find Patent Forward Citations

Ingber, Donald. (2014). Methods for the modulation of angiogenesis (U.S. Patent No. 8722638). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8722638

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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