The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2014
Filed:
Mar. 30, 2011
Roger Prichard, Ste-Anne-de-Bellevue, CA;
Catherine Bourguinat, Montreal, CA;
Timothy Geary, Ste-Anne-de-Bellevue, CA;
Rudolf Schenker, Basel, CH;
Roger Prichard, Ste-Anne-de-Bellevue, CA;
Catherine Bourguinat, Montreal, CA;
Timothy Geary, Ste-Anne-de-Bellevue, CA;
Rudolf Schenker, Basel, CH;
The Royal Institution for the Advancement of Learning/McGill University, Montreal, Quebec, CA;
Novartis AG, Basel, CH;
Abstract
The invention relates to a method for determining the responsiveness of aspp. nematode to a macrocyclic lactone, by determining the genotype of the nematode at a position in a P-glycoprotein gene of the nematode corresponding to position 11, and optionally to position 618, in SEQ ID NO: 1, wherein the genotype GG at a position corresponding to position 11, or at positions corresponding to positions 11 and 618, in SEQ ID NO: 1 indicates that the nematode is likely resistant to the macrocyclic lactone. The invention also relates to methods for selecting a treatment to treat an animal infected with macrocyclic lactone resistantspp nematode, and treating the animal; or for selecting a prophylactic to prevent an animal from becoming infected with a macrocyclic lactone resistantspp nematode, and providing the prophylactic to the animal. The invention further relates to an isolated nucleic acid having at least 80% sequence identity to SEQ ID NO: 1.