The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2014
Filed:
Sep. 29, 2010
Applicants:
Hans Stauss, London, GB;
Shao-an Xue, London, GB;
Inventors:
Hans Stauss, London, GB;
Shao-An Xue, London, GB;
Assignee:
UCL Business PLC, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/42 (2006.01); C07K 14/725 (2006.01); C07K 14/045 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); C07K 14/045 (2013.01); C12N 2799/027 (2013.01);
Abstract
The present invention provides a T-cell receptor (TCR) which binds to a peptide from the cytomegalovirus (CMV) phosphoprotein pp65 having the amino acid sequence NLVPMVATV (SEQ ID No. 1) when presented by a major histocompatability complex (MHC) molecule. The present invention also provides a nucleotide sequence encoding such a TCR, a vector comprising such a nucleotide sequence and its use to produce a CMV-specific T-cell. The present invention also provides the use of CMV-specific T-cell for cellular immunotherapy.