The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2014
Filed:
Aug. 11, 2010
Applicants:
Ralph Mazitschek, Belmont, MA (US);
James Elliot Bradner, Cambridge, MA (US);
Inventors:
Ralph Mazitschek, Belmont, MA (US);
James Elliot Bradner, Cambridge, MA (US);
Assignees:
President and Fellows of Harvard College, Cambridge, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/05 (2006.01); A61K 31/495 (2006.01); C12Q 1/48 (2006.01); A61K 45/06 (2006.01); C07D 239/42 (2006.01); C07D 401/04 (2006.01);
U.S. Cl.
CPC ...
A61K 38/05 (2013.01); A61K 45/06 (2013.01); A61K 31/495 (2013.01); C07D 239/42 (2013.01); C07D 401/04 (2013.01); C12Q 1/48 (2013.01);
Abstract
The present invention relates to compounds of the following formula wherein Ris a fluorescent tag. Another aspect of the invention provides an assay for determining the inhibitory effect of a test compound on an HDAC protein comprising: incubating the HDAC protein with a substrate of the above formula in the presence of a test compound; and determining the activity of the HDAC protein.