The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2014
Filed:
Oct. 27, 2011
Yves Pommier, Bethesda, MD (US);
Christophe Marchand, Silver Spring, MD (US);
Periyasamy Selvam, Kerala, IN;
Thomas Dexheimer, Montgomery Village, MD (US);
Kasthuraiah Maddali, Rockville, MD (US);
Yves Pommier, Bethesda, MD (US);
Christophe Marchand, Silver Spring, MD (US);
Periyasamy Selvam, Kerala, IN;
Thomas Dexheimer, Montgomery Village, MD (US);
Kasthuraiah Maddali, Rockville, MD (US);
Other;
Abstract
A method for treating cancer in a subject, comprising administering to a subject having cancer a therapeutically effective amount of (i) a fluoroquinolone derivative that inhibits tyrosyl-DNA-phosphodiesterase 1 (Tdp1) activity or (ii) a sulfonamide moiety-containing compound that inhibits tyrosyl-DNA-phosphodiesterase 1 (Tdp1) activity, thereby treating the cancer in the subject. In certain embodiments, the fluoroquinolone derivative or sulfonamide moiety-containing compound is co-administered with a topoisomerase I (TopI) inhibitor.