The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2014
Filed:
Jun. 03, 2011
Suh-hang Juo, Kaohsiung, TW;
Ku-chung Chen, Kaohsiung, TW;
I-chung Hsieh, Kaohsiung, TW;
Ching-yu HU, Kaohsiung, TW;
Suh-Hang Juo, Kaohsiung, TW;
Ku-Chung Chen, Kaohsiung, TW;
I-Chung Hsieh, Kaohsiung, TW;
Ching-Yu Hu, Kaohsiung, TW;
Kaoshiung Medical University, Kaohsiung, TW;
Abstract
There is provided a method of therapy of atherosclerosis, by providing microRNA let-7g, an analogue thereof or modified let-7g to organisms to inhibit the expression of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1), and the binding of LOX-1 and oxidized low-density lipoprotein (oxLDL), so as to block the pathogenesis of atherosclerosis. Also, a method of diagnosis of atherosclerosis comprises determining the levels of microRNA let-7g in serum or plasma samples of organisms, in which the levels of microRNA let-7g is estimated in individuals with atherosclerosis as compared to individuals without atherosclerosis.