The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2014
Filed:
Nov. 10, 2006
Guido Cappuccilli, San Mateo, CA (US);
Roberto Crea, San Mateo, CA (US);
Takeuchi Toshihilo, Oakland, CA (US);
Randy Shen, Sunnyvale, CA (US);
Ramesh R. Bhatt, Belmont, CA (US);
Nurten Beyaz-kavuncu, Chesterfield, MO (US);
Guido Cappuccilli, San Mateo, CA (US);
Roberto Crea, San Mateo, CA (US);
Takeuchi Toshihilo, Oakland, CA (US);
Randy Shen, Sunnyvale, CA (US);
Ramesh R. Bhatt, Belmont, CA (US);
Nurten Beyaz-Kavuncu, Chesterfield, MO (US);
Bioren, Inc., Chesterfield, MO (US);
Abstract
Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries, are disclosed. The disclosed processes involve use of a query CDR sequence to guide incorporation of human antibody diversity present within the reference library into cohort libraries of the invention. Methods for making and screening such cohort libraries for isolating therapeutics suitable for treating disease are also disclosed.