The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2014
Filed:
Feb. 03, 2009
Applicants:
Shun-ichi Sekine, Tokyo, JP;
Ryuya Fukunaga, Tokyo, JP;
Shigeyuki Yokoyama, Kanagawa, JP;
Ichiro Hirao, Kanagawa, JP;
Yoko Harada, Kanagawa, JP;
Inventors:
Shun-ichi Sekine, Tokyo, JP;
Ryuya Fukunaga, Tokyo, JP;
Shigeyuki Yokoyama, Kanagawa, JP;
Ichiro Hirao, Kanagawa, JP;
Yoko Harada, Kanagawa, JP;
Assignee:
Riken, Saitama, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/00 (2006.01); C12P 21/06 (2006.01);
U.S. Cl.
CPC ...
Abstract
In the method for introducing a noncanonical amino acid residue into a desired position in a protein, the structure of tRNA is so modified as to have improved affinity for aminoacyl-tRNA synthetase or improved specificity to aminoacyl-tRNA synthetase. An unnatural base is contained at any position in tRNA, whereby the efficiency of aminoacylation of the tRNA with a noncanonical amino acid can be improved.