The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2014
Filed:
Aug. 03, 2010
Applicants:
Guy Dequesne, Rixensart, BE;
Sophie Marie Jeanne Valentine Germain, Rixensart, BE;
Inventors:
Guy Dequesne, Rixensart, BE;
Sophie Marie Jeanne Valentine Germain, Rixensart, BE;
Assignee:
GlaxoSmithKline Biologicals S.A., Rixensart, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/085 (2006.01); C07K 14/31 (2006.01); C12N 15/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to ClfA polypeptides wherein amino acid Y474 or an amino acid adjacent to Y474 is mutated such that fibrinogen binding activity is decreased compared to an equivalent ClfA polypeptide without mutation of Y474 or an amino acid adjacent to Y474 as well as immunogenic compositions, vaccines, processes and uses of such mutated ClfA polypeptides.