The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2014
Filed:
Aug. 14, 2012
Peter Kwong, Washington, DC (US);
John Mascola, Rockville, MD (US);
Gary Nabel, Washington, DC (US);
Richard Wyatt, Rockville, MD (US);
Barna Dey, Germantown, MD (US);
Ling Xu, Potomac, MD (US);
Tongqing Zhou, Boyds, MD (US);
Joseph Sodroski, Boston, MA (US);
Wen Yuan, Brighton, MA (US);
Shi-hua Xiang, Boston, MA (US);
Peter Kwong, Washington, DC (US);
John Mascola, Rockville, MD (US);
Gary Nabel, Washington, DC (US);
Richard Wyatt, Rockville, MD (US);
Barna Dey, Germantown, MD (US);
Ling Xu, Potomac, MD (US);
Tongqing Zhou, Boyds, MD (US);
Joseph Sodroski, Boston, MA (US);
Wen Yuan, Brighton, MA (US);
Shi-Hua Xiang, Boston, MA (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
Dana-Faber Cancer Institute, Inc., Boston, MA (US);
Abstract
Isolated immunogens including a HIV-1 gp120 polypeptide or immunogenic fragment thereof stabilized in a CD4 bound confirmation by crosslinked cysteines, and methods of their use are disclosed. The immunogens are useful, for example, for generating an immune response to HIV-1 gp120 in a subject.