The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2014
Filed:
Aug. 28, 2008
Jonathan M. Gershoni, Herzliya, IL;
Gal Dela, Kiryat Ono, IL;
Jonathan M. Gershoni, Herzliya, IL;
Gal Dela, Kiryat Ono, IL;
Ramot at Tel Aviv University Ltd., Tel Aviv, IL;
Abstract
A novel peptides are complexed with HIV-I envelope protein gp120, and causes the protein to assume a CD4i conformation but without occluding the CD4 binding-site of gp120. This peptide-gp120 complex is immunogenic and, upon immunization of subjects, induces broadly-neutralizing antibodies directed to the CD4 binding site of gp120. The peptide preferably consists of a sequence of 8-20 amino acid residues which comprises (a) a core sequence Arg-Xaa-Asp-Leu-Pro-Xaa-Trp-Ala (SEQ ID NO: 1) in which Xaaand Xaais any amino acid, or (b) certain substitution variants of SEQ ID NO:1.